A clean out sub for use in a drill string having a tool body with a cavity for passage of drilling fluid and annular fluid circulation ports extending through the tool body, a valve spool is positioned within the tool body cavity having a reduced diameter orifice, a compression spring is located within the tool body cavity adjacent the valve spool, wherein a drop in fluid pressure created by the orifice imparts a downhole force on the valve spool and at a predetermined force overcomes a set resistive force of the compression spring thereby moving the valve spool to open the annular fluid circulation ports.