A faucet with a quickly replaceable valve cartridge may include a faucet body, a valve cartridge base and a locating unit. The valve cartridge base is configured to provide an accommodating space for a valve cartridge, and the faucet body has a first chamber to receive the valve cartridge base, and the locating unit is configured to secure the valve cartridge base inside of the faucet body. When the valve cartridge of the faucet needs to be cleaned or replaced, by disengaging the locating unit from the faucet body, the valve cartridge base can be moved from the first chamber. Furthermore, the user can readily take out the valve cartridge from the valve cartridge base after disengaging an engaging ring from the valve cartridge base thereby achieving the quickly replaceable effect of the faucet valve cartridge.