A two-way speech-to-speech (S2S) translation system actively detects a wide variety of common error types and resolves them through user-friendly dialog with the user(s). Examples include features including one or more of detecting out-of-vocabulary (OOV) named entities and terms, sensing ambiguities, homophones, idioms, ill-formed input, etc. and interactive strategies for recovering from such errors. In some examples, different error types are prioritized and systems implementing the approach can include an extensible architecture for implementing these decisions.