A composition for endodontic irrigation is provided. The composition includes a chemical depilatory during intra-canal, and chemo-mechanical instrumentation in endodontic. The composition includes calcium hydroxide or potassium hydroxide, sodium hydroxide, and potassium thioglycolate or calcium thioglycolate to form an effective root canal medicament. Further, the composition may incorporate mineral oil, urea, cetearyl alcohol, D&C yellow No. 8, chromium hydroxide, theobroma cocoa seed butter, iron oxides, fragrances, and ceteareth-20 to enhance its functioning. The composition disinfects, lubricates, chelates, irrigants, dissolves, and facilitates removal of the pulpal tissue and debris. Furthermore, the composition reduces and even eliminates bacteria from micro-endodontic systems. Further, the composition of the present invention enhances eradicating pathogens along with chemo-mechanical debridement of the root canal system.