Invention Grant
- Patent Title: Methods of treating and preventing leukemia and other cancers of the blood and bone
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Application No.: US14355355Application Date: 2012-11-16
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Publication No.: US09717727B2Publication Date: 2017-08-01
- Inventor: Stavroula Kousteni
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Leason Ellis LLP
- International Application: PCT/US2012/065458 WO 20121116
- International Announcement: WO2013/074889 WO 20130523
- Main IPC: A61K31/505
- IPC: A61K31/505
Abstract:
The present invention relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by inhibiting gut-derived serotonin. The inhibition of the gut-derived serotonin is accomplished by inhibiting Tph1, an enzyme responsible for the production of gut-derived serotonin. The present invention also relates to preventing and treating leukemia and other cancers of the blood and bone, as well as disorders of the blood, by increasing the number, growth and proliferation of osteoblasts.
Public/Granted literature
- US20140303197A1 METHODS OF TREATING AND PREVENTING LEUKEMIA AND OTHER CANCERS OF THE BLOOD AND BONE Public/Granted day:2014-10-09
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