A computer-implemented method, system, and/or computer program product automatically provide spatial separation between self-driving vehicles (SDVs) operating in an autonomous mode and vehicles being operating in a manual mode on a roadway. A first SDV operating on the roadway is operating in autonomous mode. A second vehicle may be operating in the autonomous mode or a manual mode, in which a driver is controlling the second vehicle. Processor(s) issue spatial separation instructions to the first SDV, which direct SDV control mechanisms controller on the first SDV to direct a set of SDV vehicular physical control mechanisms on the first SDV to provide a predetermined amount of spatial separation between the first SDV and the second vehicle, based on whether the second vehicle is being operated in the manual mode or in the autonomous mode.