Invention Grant
- Patent Title: Plasminogen activator inhibitor-1 inhibitors and methods of use thereof
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Application No.: US14439843Application Date: 2013-10-31
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Publication No.: US09718760B2Publication Date: 2017-08-01
- Inventor: Daniel A. Lawrence , Cory Emal , Ashley Reinke , Shih-Hon Li , Mark Warnock , Gregory Abernathy
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN , EASTERN MICHIGAN UNIVERSITY
- Applicant Address: US MI Ann Arbor US MI Ypsilanti
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,EASTERN MICHIGAN UNIVERSITY
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN,EASTERN MICHIGAN UNIVERSITY
- Current Assignee Address: US MI Ann Arbor US MI Ypsilanti
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2013/067695 WO 20131031
- International Announcement: WO2014/070983 WO 20140508
- Main IPC: C07C243/26
- IPC: C07C243/26 ; C07C69/84 ; C07C259/06 ; C07C271/16 ; C07C275/64 ; C07C311/17 ; C07C311/29 ; C07C311/48 ; C07C311/49 ; C07D417/04 ; C07C323/60 ; C07D249/08 ; C07C233/13 ; C07C233/56 ; C07D261/18 ; C07C235/34 ; C07C235/46 ; C07D271/113 ; C07D277/34 ; C07D207/48 ; C07C251/76 ; C07D209/08 ; C07D209/34 ; C07D213/42
Abstract:
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.
Public/Granted literature
- US20150315178A1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF Public/Granted day:2015-11-05
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