Invention Grant
- Patent Title: Aniline derivative, pharmaceutical composition containing same, and use thereof
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Application No.: US15121522Application Date: 2015-02-27
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Publication No.: US09718771B2Publication Date: 2017-08-01
- Inventor: Hitoshi Inoue , Kohsuke Ohno , Tetsuya Nakamura , Yusuke Ohsawa
- Applicant: Kissei Pharmaceutical Co., Ltd.
- Applicant Address: JP Matsumoto, Nagano
- Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee: KISSEI PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Matsumoto, Nagano
- Agency: Westerman, Hattori, Daniels & Adrian, LLP
- Priority: JP2014-037823 20140228
- International Application: PCT/JP2015/055867 WO 20150227
- International Announcement: WO2015/129859 WO 20150903
- Main IPC: C07D205/04
- IPC: C07D205/04

Abstract:
A compound having an S1P1 receptor antagonistic activity. A compound represented by general formula (I): (in the formula, R1, R2 and R3 are each a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group or the like, R4 is a C1-6 alkyl group or the like, R5 is a C1-6 alkyl group or the like, R6 is a C1-6 alkyl group or the like, R7 is a hydrogen atom, a halogen atom, a C1-6 alkyl group or the like, R8 is a halogen atom, a C1-6 alkyl group, a halo C1-6 alkyl group, a C1-6 alkoxy group or the like, and R9 is a hydrogen atom or a C1-6 alkyl group.) or a pharmaceutically acceptable salt thereof, a pharmaceutical compositions containing same, and use thereof. The compounds have an excellent S1P1 receptor antagonistic activity and are useful for the treatment or prevention of autoimmune diseases.
Public/Granted literature
- US20160362368A1 NOVEL ANILINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF Public/Granted day:2016-12-15
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