Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassium channel
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Application No.: US15106847Application Date: 2015-01-05
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Publication No.: US09718808B2Publication Date: 2017-08-01
- Inventor: Dipshikha Biswas , Fa-Xiang Ding , Shuzhi Dong , Xin Gu , Jinlong Jiang , Alexander Pasternak , Takao Suzuki , Joseph Vacca , Shouning Xu
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- Priority: WOPCT/CN2014/070384 20140109
- International Application: PCT/US2015/010091 WO 20150105
- International Announcement: WO2015/105736 WO 20150716
- Main IPC: A61K31/501
- IPC: A61K31/501 ; A61K31/403 ; A61K31/4439 ; A61K31/497 ; A61K31/437 ; A61K31/427 ; A61K31/41 ; C07D405/14 ; C07D487/04 ; C07D413/14 ; C07D471/04 ; C07D417/14 ; A61K31/506 ; A61K45/06
Abstract:
The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Public/Granted literature
- US20170037037A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL Public/Granted day:2017-02-09
Information query
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