Invention Grant
- Patent Title: N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides and their use as pharmaceuticals
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Application No.: US14775620Application Date: 2014-03-12
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Publication No.: US09718825B2Publication Date: 2017-08-01
- Inventor: Marc Nazare , Nis Halland , Friedemann Schmidt , Heinz-Werner Kleemann , Tilo Weiss , Joachim Saas , Carsten Struebing
- Applicant: SANOFI
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP13305283 20130313
- International Application: PCT/EP2014/054770 WO 20140312
- International Announcement: WO2014/140065 WO 20140918
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; A61K31/4162

Abstract:
The present invention relates to N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides of the formula I, wherein Ar, n, X, Z, R1, R2 and R3 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds which modulate protein kinase activity, specifically the activity of serum and glucocorticoid regulated kinase (SGK), in particular of serum and glucocorticoid regulated kinase isoform 1 (SGK-1, SGK1), and are suitable for the treatment of diseases in which SGK activity is inappropriate, for example degenerative joint disorders or inflammatory processes such as osteoarthritis or rheumatism. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.
Public/Granted literature
- US20160024097A1 N-(4-(AZAINDAZOL-6-YL)-PHENYL)-SULFONAMIDES AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2016-01-28
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