Invention Grant
- Patent Title: Compounds useful as inhibitors of ATR kinase
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Application No.: US15142338Application Date: 2016-04-29
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Publication No.: US09718827B2Publication Date: 2017-08-01
- Inventor: Nadia Ahmad , Dean Boyall , Jean-Damien Charrier , Christopher John Davis , Rebecca Davis , Steven John Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Marcellus Alphonsus Knegtel , Donald Middleton , Michael Edward O'Donnell , Maninder Panesar , Francoise Yvonne Theodora Marie Pierard , Joanne Pinder , David Matthew Shaw , Pierre-Henri Storck , John R. Studley , Heather Twin
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Dechert LLP
- Agent Andrea L.C. Reid
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D453/02 ; C07D471/08 ; C07D487/08 ; C07D491/107 ; C07D498/04 ; C07D498/10

Abstract:
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
Public/Granted literature
- US20160347754A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE Public/Granted day:2016-12-01
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