• Patent Title: Tritoqualine hydrochloride in crystalline form and a process for obtaining same
  • Application No.: US15104006
    Application Date: 2014-12-29
  • Publication No.: US09718833B2
    Publication Date: 2017-08-01
  • Inventor: Patrice Binay
  • Applicant: Patrice Binay
  • Agency: Oliff PLC
  • Priority: FR1303107 20131230
  • International Application: PCT/FR2014/000306 WO 20141229
  • International Announcement: WO2015/101727 WO 20150709
  • Main IPC: C07D491/056
  • IPC: C07D491/056
Tritoqualine hydrochloride in crystalline form and a process for obtaining same
Abstract:
A crystalline form of tritoqualine hydrochloride and also a process for obtaining same. The process for obtaining tritoqualine hydrochloride is made of dissolving tritoqualine base in an alcohol, in particular a lower aliphatic alcohol, such as ethanol, in the presence of hydrochloric acid until a solution in the supersaturated state is obtained. Through successive additions of ether, in particular of ethyl ether, the tritoqualine hydrochloride will subsequently be able to crystallize. The product can be applied to the preparation of pharmaceutical formulations.
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