Invention Grant
- Patent Title: Sodium channel blocking peptides and the use thereof
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Application No.: US14417394Application Date: 2013-07-26
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Publication No.: US09718865B2Publication Date: 2017-08-01
- Inventor: Donald James Kyle , Jae Hyun Park
- Applicant: Purdue Pharma L.P.
- Applicant Address: US CT Stamford
- Assignee: Purdue Pharma L.P.
- Current Assignee: Purdue Pharma L.P.
- Current Assignee Address: US CT Stamford
- Agency: Purdue Pharma L.P.
- Agent Alan L. Koller; Weiying Yang
- International Application: PCT/IB2013/001653 WO 20130726
- International Announcement: WO2014/016673 WO 20140130
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/435 ; A61K38/00
Abstract:
The present invention relates to C-terminal modified Protoxin II peptides that selectively inhibit the Nav1.7 sodium channel; the present invention also relates to pharmaceutical compositions useful for prophylactic or therapeutic treatment of a disorder responsive to the blockade of sodium ion channels, especially Nav1.7 sodium ion channels; the present invention further provides methods of treating a disorder responsive to the blockade of sodium channels, and particularly Nav1.7 sodium channels, in a mammal suffering from excess activity of said channels.
Public/Granted literature
- US20150191517A1 NOVEL SODIUM CHANNEL BLOCKING PEPTIDES AND THE USE THEREOF Public/Granted day:2015-07-09
Information query
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