Invention Grant
- Patent Title: Anti-TNF-/anti-IL-23 bispecific antibodies
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Application No.: US14930678Application Date: 2015-11-03
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Publication No.: US09718884B2Publication Date: 2017-08-01
- Inventor: Rohn L Millican, Jr. , Neungseon Seo , Songqing Na , Catherine B. Beidler
- Applicant: Eli Lilly and Company
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Duane C. Marks
- Main IPC: C07K16/24
- IPC: C07K16/24 ; A61K39/395 ; C12N15/13 ; C07K16/28 ; A61K39/00

Abstract:
Bispecific antibodies are provided that bind Tumor Necrosis Factor alpha (TNFα) and the p19 subunit of Interleukin-23 (IL-23p19) and are characterized as having high affinity and strong simultaneous neutralizing properties to both TNFα and IL-23. The bispecific antibodies of the invention are useful for treating various autoimmune diseases including Inflammatory Bowel Disease, such as Crohn's Disease and Ulcerative Colitis, Axial Spondyloarthropathy, Rheumatoid Arthritis and Psoriatic Arthritis.
Public/Granted literature
- US20160122429A1 ANTI-TNF- / ANTI-IL-23 BISPECIFIC ANTIBODIES Public/Granted day:2016-05-05
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