- Patent Title: Methods of predicting ancestral virus sequences and uses thereof
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Application No.: US15291470Application Date: 2016-10-12
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Publication No.: US09719070B2Publication Date: 2017-08-01
- Inventor: Luk H. Vandenberghe , Eric Zinn
- Applicant: Massachusetts Eye and Ear Infirmary , Schepens Eye Research Institute
- Applicant Address: US MA Boston US MA Boston
- Assignee: Massachusetts Eye and Ear Infirmary,Schepens Eye Research Institute
- Current Assignee: Massachusetts Eye and Ear Infirmary,Schepens Eye Research Institute
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: A61K39/23
- IPC: A61K39/23 ; A61K39/00 ; C12N7/00 ; C07K14/00 ; C12N15/86 ; C07K14/005 ; C07K16/22
Abstract:
Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
Public/Granted literature
- US20170051257A1 METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF Public/Granted day:2017-02-23
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