Invention Grant
- Patent Title: Co-transcriptional assembly of modified RNA nanoparticles
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Application No.: US14426707Application Date: 2013-09-06
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Publication No.: US09719084B2Publication Date: 2017-08-01
- Inventor: Bruce A. Shapiro , Kirill A. Afonin , Maria L. Kireeva , Mikhail Kashlev , Luc Jaeger , Wade W. Grabow
- Applicant: The United States of America, as represented by the Secretary, Department of Health & Human Services , The Regents of the University of California
- Applicant Address: US DC Washington US CA Oakland
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services,The Regents of the University of California
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services,The Regents of the University of California
- Current Assignee Address: US DC Washington US CA Oakland
- Agency: Locke Lord LLP
- Agent Gabriel J. McCool
- International Application: PCT/US2013/058492 WO 20130906
- International Announcement: WO2014/039809 WO 20140313
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12N15/11
Abstract:
A method is provided for generating RNA nanoparticles having modified nucleotides and/or having increased nuclease resistance where the RNA nanoparticles are formed cotranscriptionally by T7 RNA polymerase in the presence of manganese ions.
Public/Granted literature
- US20150203842A1 CO-TRANSCRIPTIONAL ASSEMBLY OF MODIFIED RNA NANOPARTICLES Public/Granted day:2015-07-23
Information query
