Invention Grant
- Patent Title: Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
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Application No.: US14810148Application Date: 2015-07-27
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Publication No.: US09719091B2Publication Date: 2017-08-01
- Inventor: Masad J. Damha , Jonathan K. Watts , Glen Deleavey
- Applicant: PALADIN LABS INC.
- Applicant Address: CA Montréal
- Assignee: Paladin Labs, Inc.
- Current Assignee: Paladin Labs, Inc.
- Current Assignee Address: CA Montréal
- Agency: Goodwin Procter LLP
- Priority: CA2635187 20080617; WOPCT/CA2008/002259 20080617
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/00 ; C07H21/02 ; C12N15/11 ; C12N15/113
Abstract:
Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2′-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2′-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
Public/Granted literature
- US20160145613A1 OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF Public/Granted day:2016-05-26
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