- Patent Title: Substrates and optical systems and methods of use thereof having a single optically resolvable immobilized reaction component disposed within a nanometer-scale aperture
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Application No.: US14949313Application Date: 2015-11-23
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Publication No.: US09719138B2Publication Date: 2017-08-01
- Inventor: Cheng Frank Zhong , Paul Lundquist , Mathieu Foquet , Jonas Korlach , Hovig Bayandorian
- Applicant: Pacific Biosciences of California, Inc.
- Applicant Address: US CA Menlo Park
- Assignee: Pacific Biosciences of California, Inc.
- Current Assignee: Pacific Biosciences of California, Inc.
- Current Assignee Address: US CA Menlo Park
- Agent David C. Scherer
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N21/64 ; G01N21/77 ; G01N33/543
Abstract:
This invention provides substrates for use in various applications, including single-molecule analytical reactions. Methods for propagating optical energy within a substrate are provided. Devices comprising waveguide substrates and dielectric omnidirectional reflectors are provided. Waveguide substrates with improved uniformity of optical energy intensity across one or more waveguides and enhanced waveguide illumination efficiency within an analytic detection region of the arrays are provided.
Public/Granted literature
- US20160153040A1 SUBSTRATES AND OPTICAL SYSTEMS AND METHODS OF USE THEREOF Public/Granted day:2016-06-02
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