A method of operation of a device programming system includes: providing a target programmer, having a programming bus; coupling an electronic device, having a non-volatile memory, to the target programmer by the programming bus; and programming a data image into the non-volatile memory by the target programmer includes: subscribing to a broadcast message, receiving a logical block, of the data image, by the broadcast message for programming the non-volatile memory, and sending an unsubscribe message after receiving the logical blocks of the data image from the broadcast message.