A system and method of efficiently inspecting content is provided. Embodiments of the invention may inspect files accessed by an application prior to an activation of the application. Selective inspection of files accessed by an application may be based on a previous inspection. Inspection of files accessed by an application may be postponed or performed concurrently with the access. A prioritized queue may include references to files, a priority may be related to a risk level and an inspection order may be according to a risk level.