A method and a system for handling in-device coexistence interference in a user equipment are provided. The method includes detecting in-device coexistence interference between one or more of a plurality of carrier frequencies of Long Term Evolution (LTE) radio technology and at least one frequency of non-LTE radio technologies, determining at least one of the one or more of the plurality of LTE carrier frequencies for which a measurement object is configured, and transmitting interference information associated with the at least one LTE carrier frequency affected by the in-device coexistence interference. The interference information includes a measurement object identifier of the at least one carrier LTE frequency, Direction of Interference (DOI), and time domain multiplexing assistance information. The method further includes receiving a configured method from the network entity which help mitigate the in-device coexistence interference at the user equipment.