A gamma correction circuit applied to a display device includes a first storage unit, a second storage unit, a first correction circuit and a second correction circuit. The first storage unit stores a first gamma look-up table, and the second storage unit stores a second gamma look-up table. The first correction circuit receives an input signal, and generates an intermediate signal corresponding to the input signal according to the first gamma look-up table. The second correction circuit receives the intermediate signal, and generates an output signal corresponding to the intermediate signal according to the second look-up table to a display panel. The first look-up table is stored to the first storage unit after the display device is powered on.