In a base station having a Massive Multiple Input Multiple Output (M-MIMO) antenna array, the availability of the M-MIMO antenna array is exploited to manage the interference caused by the base station to neighboring cells. In one embodiment, the large number of antenna elements of the M-MIMO antenna array are used to create precise transmit and/or receive spatial nulls at specific User Equipments (UEs) being served by a neighboring cell and/or in select areas of the neighboring cell. Depending on whether the spatial null is partial or full, transmissions by the base station may have reduced or even zero receive power within the neighboring cell.