Invention Grant
- Patent Title: Immunomodulation by IAP inhibitors
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Application No.: US12992631Application Date: 2009-05-14
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Publication No.: US09750729B2Publication Date: 2017-09-05
- Inventor: Leigh Zawel , Christopher S. Straub , Brant G. Firestone , Glenn Dranoff , Michael Dougan
- Applicant: Leigh Zawel , Christopher S. Straub , Brant G. Firestone , Glenn Dranoff , Michael Dougan
- Applicant Address: US MA Boston CH Basel
- Assignee: Dana-Farber Cancer Institute, Inc.,Novartis AG
- Current Assignee: Dana-Farber Cancer Institute, Inc.,Novartis AG
- Current Assignee Address: US MA Boston CH Basel
- Agency: Brinks Gilson & Lione
- International Application: PCT/US2009/043874 WO 20090514
- International Announcement: WO2009/140447 WO 20091119
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/33 ; A61K31/4439 ; A61K31/421 ; A61K31/427 ; A61K31/506 ; A61K39/00 ; A61K39/39
Abstract:
The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
Public/Granted literature
- US20110135691A1 IMMUNOMODULATION BY IAP INHIBITORS Public/Granted day:2011-06-09
Information query
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