Invention Grant
- Patent Title: IL-18 inhibition for promotion of early hematopoietic progenitor expansion
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Application No.: US14760076Application Date: 2014-01-14
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Publication No.: US09750767B2Publication Date: 2017-09-05
- Inventor: David T. Scadden , Lev Silberstein , Peter Kharchenko
- Applicant: THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Applicant Address: US MA Boston US MA Cambridge
- Assignee: THE GENERAL HOSPITAL CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee: THE GENERAL HOSPITAL CORPORATION,PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- Current Assignee Address: US MA Boston US MA Cambridge
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Shayne Y. Huff
- International Application: PCT/US2014/011445 WO 20140114
- International Announcement: WO2014/110560 WO 20140717
- Main IPC: A61K35/28
- IPC: A61K35/28 ; A61K38/17 ; A61K38/20 ; A61K35/12
Abstract:
Disclosed herein are methods for enhancing hematopoietic reconstitution of a subject. One method involves administering a therapeutically effective amount of an inhibitor of IL-18 to a recipient subject and also administering hematopoietic stem/progenitor cells to the subject. Another method involves administering an inhibitor of IL-18 to a donor prior to harvest of hematopoietic stem/progenitor cells. Pharmaceutical compositions relating to the methods are also described.
Public/Granted literature
- US20160030481A1 IL-18 INHIBITION FOR PROMOTION OF EARLY HEMATOPOIETIC PROGENITOR EXPANSION Public/Granted day:2016-02-04
Information query
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