- Patent Title: Use of matrix metalloproteinase inhibitors to treat tuberculosis
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Application No.: US14000134Application Date: 2012-02-17
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Publication No.: US09750789B2Publication Date: 2017-09-05
- Inventor: Jeanine D'armiento , Paul Elkington , Jon S. Friedland
- Applicant: Jeanine D'armiento , Paul Elkington , Jon S. Friedland
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White; Gary J. Gershik
- International Application: PCT/US2012/025728 WO 20120217
- International Announcement: WO2012/112945 WO 20120823
- Main IPC: A61K39/04
- IPC: A61K39/04 ; A61K39/395 ; A61K39/00 ; A61K38/55 ; A61K31/166 ; A61K31/197 ; A61K31/4439 ; A61K31/5377 ; A61K31/65 ; A61K38/48
Abstract:
The present invention provides a method for treating a subject suffering from tuberculosis which comprises administering to the subject a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to treat the subject, such that the therapeutic effect of said composition is different than the therapeutic effect attributable to the antibiotic properties of said composition. The present invention also provides a method for reducing or inhibiting destruction of lung extracellular matrix in a subject comprising administering to the subject at risk for such destruction a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to reduce or inhibit destruction of lung extracellular matrix in the subject.
Public/Granted literature
- US20140199289A1 USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS Public/Granted day:2014-07-17
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