Invention Grant
- Patent Title: Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders
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Application No.: US15036212Application Date: 2014-11-17
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Publication No.: US09751824B2Publication Date: 2017-09-05
- Inventor: Patrick L. McGeer , Moonhee Lee , Edith G. McGeer
- Applicant: Aurin Biotech Inc.
- Applicant Address: unknown Vancouver, BC
- Assignee: Aurin Biotech Inc.
- Current Assignee: Aurin Biotech Inc.
- Current Assignee Address: unknown Vancouver, BC
- Agency: Oyen Wiggs Green & Mutala LLP
- International Application: PCT/CA2014/051097 WO 20141117
- International Announcement: WO2015/070354 WO 20150521
- Main IPC: A61K31/225
- IPC: A61K31/225 ; C07C69/16 ; A61K9/00 ; A61K8/37 ; A61Q5/00 ; A61Q7/00 ; A61Q19/00 ; C07C69/017
Abstract:
Dimers of acetyl salicylic acid, including 4,4′-diacetoxy-[1,1′-biphenyl]-3,3′-dicarboxylic acid (DAS-1) and 5,5′-methylenebis(2-acetoxybenzoic acid) (DAS-2) are provided. Methods of blocking the C3 convertase stage of the alternative complement pathway, preventing formation of the membrane attack complex of complement, and preventing or treating a complement-mediated disorder in a mammal including the step of administering dimers of acetyl salicylic acid are also provided.
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