Invention Grant
- Patent Title: Blood brain barrier-penetrating oximes for cholistenerases reactivation
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Application No.: US13994682Application Date: 2011-12-16
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Publication No.: US09751831B2Publication Date: 2017-09-05
- Inventor: John R. Cashman , Jarosiaw Kalisiak
- Applicant: John R. Cashman , Jarosiaw Kalisiak
- Applicant Address: US CA San Diego
- Assignee: Human BioMolecular Research Institute
- Current Assignee: Human BioMolecular Research Institute
- Current Assignee Address: US CA San Diego
- International Application: PCT/US2011/065655 WO 20111216
- International Announcement: WO2012/083261 WO 20120621
- Main IPC: C07D249/04
- IPC: C07D249/04 ; C07D239/06 ; C07D233/24 ; C07C251/40 ; C07C279/12 ; C07C257/12 ; C07C257/18 ; C07C257/14
Abstract:
The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.
Public/Granted literature
- US20140051712A1 BLOOD BRAIN BARRIER-PENETRATING OXIMES FOR CHOLISTENERASES REACTIVATION Public/Granted day:2014-02-20
Information query
