Invention Grant
- Patent Title: Process for making modulators of cystic fibrosis transmembrane conductance regulator
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Application No.: US15160100Application Date: 2016-05-20
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Publication No.: US09751839B2Publication Date: 2017-09-05
- Inventor: John Demattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Yap Guerette , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. Van Goor , Martyn C. Botfield , Gregor Zlokarnik
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: C07D215/56
- IPC: C07D215/56 ; C07C229/66 ; C07D215/233 ; C07C69/96 ; G01N33/50 ; G01N33/68 ; C07C68/02 ; C07C201/08 ; C07C213/02
Abstract:
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
Public/Granted literature
- US20170096396A1 PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Public/Granted day:2017-04-06
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