Invention Grant
- Patent Title: 5-HT2B antagonists
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Application No.: US15292143Application Date: 2016-10-13
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Publication No.: US09751845B2Publication Date: 2017-09-05
- Inventor: Niu Huang , Yu Zhou , Xingyu Lin
- Applicant: National Institute of Biological Sciences, Beijing
- Applicant Address: CN Beijing
- Assignee: National Institute of Biological Sciences, Beijing
- Current Assignee: National Institute of Biological Sciences, Beijing
- Current Assignee Address: CN Beijing
- Agent Richard Aron Osman
- Main IPC: A61K31/53
- IPC: A61K31/53 ; C07D251/72 ; A61K45/06 ; C07D251/10
Abstract:
The invention provides novel compounds and compositions comprising a 5-HT2B antagonist of formula I: and related methods for treating a person having a disorder characterized by undesirable 5-HT2B receptor signaling, such as migraine, irritable bowel syndrome (IBS), pulmonary arterial hypertension (PAH), fibrosis, hepatocellular cancer, a small intestinal neuroendocrine tumor, cardiovascular disorders, and gastrointestinal (GI) tract disorders.
Public/Granted literature
- US20170029385A1 5-HT2B Antagonists Public/Granted day:2017-02-02
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