Invention Grant
- Patent Title: N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase
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Application No.: US15105154Application Date: 2014-11-19
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Publication No.: US09751861B2Publication Date: 2017-09-05
- Inventor: Hans-Peter Buchstaller
- Applicant: MERCK PATENT GMBH
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP13005865 20131217
- International Application: PCT/EP2014/003086 WO 20141119
- International Announcement: WO2015/090496 WO 20150625
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/04 ; C07D413/04 ; C07D417/14 ; A61K31/454 ; A61K31/4545 ; A61K31/501 ; A61K31/506
Abstract:
Compounds of the formula (I) in which R, R1 and R3 have the meanings indicated in claim 1, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.
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