Invention Grant
![Imidazo[1,2-b]pyridazine derivatives as kinase inhibitors](/docs/US/2017-09-05/US09751887B2/abs.jpg.600x600.jpg)
- Patent Title: Imidazo[1,2-b]pyridazine derivatives as kinase inhibitors
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Application No.: US14926973Application Date: 2015-10-29
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Publication No.: US09751887B2Publication Date: 2017-09-05
- Inventor: Yasuyuki Takeda , Kenji Yoshikawa , Yoshiko Kagoshima , Yuko Yamamoto , Ryoichi Tanaka , Yuichi Tominaga , Masaki Kiga , Yoshito Hamada
- Applicant: Daiichi Sankyo Company, Limited
- Applicant Address: JP Chuo-ku
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Chuo-ku
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Priority: JP2012-127079 20120604
- Main IPC: C07D487/04
- IPC: C07D487/04
![Imidazo[1,2-b]pyridazine derivatives as kinase inhibitors](/abs-image/US/2017/09/05/US09751887B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which is useful in the treatment of a tumor through its ROS1 kinase enzyme activity inhibitory effect and NTRK kinase enzyme inhibitory effect. The present invention provides a compound having an imidazo[1,2-b]pyridazine structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, G, T, Y1, Y2, Y3, and Y4 are as defined herein.
Public/Granted literature
- US20160046639A1 IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AS KINASE INHIBITORS Public/Granted day:2016-02-18
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