Invention Grant
- Patent Title: Antibodies and derivatives thereof
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Application No.: US12866184Application Date: 2009-02-04
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Publication No.: US09751947B2Publication Date: 2017-09-05
- Inventor: Fabio Benigni , Daniele D'Ambrosio
- Applicant: Fabio Benigni , Daniele D'Ambrosio
- Applicant Address: IT Rome
- Assignee: LAY LINE GENOMICS S.P.A.
- Current Assignee: LAY LINE GENOMICS S.P.A.
- Current Assignee Address: IT Rome
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/EP2009/051285 WO 20090204
- International Announcement: WO2009/098238 WO 20090813
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/28 ; A61K39/00
Abstract:
An anti-TrkA antibody is provided that comprises: a) a variable heavy chain comprising a sequence selected from any of BXhVH1, BXhVH2, BXhVH3, BXhVH4, BXhVH5, or HuVHWOv as shown in FIG. 1a; or from variants of any of said sequences and/or b) a variable light chain comprising a sequence selected from any of BXhVL1, BXhVL2, BXhVL3, BXhVL4, BXhVL5, BXhVL6, BXhVL7 or BXhVL8; as shown in FIG. 1b, or from variants of any of said sequences. TrkA-binding derivatives are also provided. Antibodies or derivatives of the present invention are useful in a number of therapies, including pain therapy.
Public/Granted literature
- US20110145941A1 ANTIBODIES AND DERIVATIVES THEREOF Public/Granted day:2011-06-16
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