Invention Grant
- Patent Title: Method of directed differentiation producing corneal endothelial cells from neural crest stem cells by PDGFB and DKK2, compositions thereof, and uses thereof
-
Application No.: US14362775Application Date: 2012-12-06
-
Publication No.: US09752118B2Publication Date: 2017-09-05
- Inventor: Kathryn L. McCabe , Shi-Jiang Lu , Robert P. Lanza
- Applicant: Astellas Institute for Regenerative Medicine
- Applicant Address: US MA Marlborough
- Assignee: Astellas Institute for Regenerative Medicine
- Current Assignee: Astellas Institute for Regenerative Medicine
- Current Assignee Address: US MA Marlborough
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2012/068305 WO 20121206
- International Announcement: WO2013/086236 WO 20130613
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/07 ; C12N5/16 ; C12N5/074 ; C12N5/079 ; A61K35/30 ; A61L27/38 ; A61K9/00 ; A61K45/06 ; C12N5/0797
Abstract:
This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells. Compositions of corneal endothelial cells and uses thereof are also provided. Exemplary compositions exhibit improved cell density and/or more “youthful” gene expression relative to cells obtained from donated tissue.
Public/Granted literature
Information query
