Invention Grant
- Patent Title: Ref nuclease for site specific Ref-mediated DNA cleavage
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Application No.: US15455255Application Date: 2017-03-10
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Publication No.: US09752133B2Publication Date: 2017-09-05
- Inventor: Michael M. Cox , Angela J. Gruber , Tayla M. Olsen
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
- Current Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: C12N15/01
- IPC: C12N15/01 ; C12N9/22 ; C12N15/113
Abstract:
Purified Ref polypeptides with increased nuclease site-specific targeting activity, recombinant nucleic acids and cells for expression of such Ref polypeptides, and methods for using the Ref polypeptides in combination with RecA protein and variants thereof to effect targeted nuclease cleavage of a DNA duplex are disclosed.
Public/Granted literature
- US20170183640A1 REF NUCLEASE FOR SITE SPECIFIC REF-MEDIATED DNA CLEAVAGE Public/Granted day:2017-06-29
Information query
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