- Patent Title: Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
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Application No.: US14514962Application Date: 2014-10-15
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Publication No.: US09752162B2Publication Date: 2017-09-05
- Inventor: Zachary Q. Beck , Michael C. Miller , Caroline M. Peres , Yuliya A. Primak , Jeff P. Pucci , Derek H. Wells
- Applicant: Danisco US Inc. , The Goodyear Tire & Rubber Company
- Applicant Address: US CA Palo Alto US OH Akron
- Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee: Danisco US Inc.,The Goodyear Tire & Rubber Company
- Current Assignee Address: US CA Palo Alto US OH Akron
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
- Main IPC: C12P5/00
- IPC: C12P5/00 ; C12N9/04 ; C12N9/10 ; C12P7/02 ; C12P7/04 ; C12P7/42 ; C12N15/70 ; C12N15/81
Abstract:
The invention features compositions and methods for the increased production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in microorganisms via the heterologous expression of the mvaE and mvaS genes from the organisms Listeria grayi DSM 20601, Enterococcus faecium, Enterococcus gallinarum EG2, and Enterococcus casseliflavus.
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