- Patent Title: Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of HLA gene amplicons using next generation systems
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Application No.: US14272752Application Date: 2014-05-08
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Publication No.: US09752189B2Publication Date: 2017-09-05
- Inventor: Henry Erlich , Bryan Hoglund , Cherie Holcomb , Priscilla Moonsamy , Nick Newton , Melinda Rastrou , Nancy Schoenbrunner , Alison Tsan , Daniel Salomon
- Applicant: Roche Molecular Systems , The Scripps Research Institute
- Applicant Address: US CA Pleasanton US CA La Jolla
- Assignee: Roche Molecular Systems, Inc.,The Scripps Research Institute
- Current Assignee: Roche Molecular Systems, Inc.,The Scripps Research Institute
- Current Assignee Address: US CA Pleasanton US CA La Jolla
- Agent Olga Kay
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific HLA alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring.
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