Invention Grant
- Patent Title: Composition for detecting undifferentiated human pluripotent stem cell, monoclonal antibody 6-1 and use thereof
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Application No.: US14806514Application Date: 2015-07-22
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Publication No.: US09752190B2Publication Date: 2017-09-05
- Inventor: Jeong Ki Min , Jongjin Park , Kwang-Hee Bae , Sang Chul Lee , Yee Sook Cho
- Applicant: Korea Research Institute of Bioscience and Biotechnology
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Agency: Lathrop & Gage LLP
- Priority: KR10-2014-0104464 20140812; KR10-2015-0099600 20150714
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C12Q1/00 ; G01N33/50 ; C12Q1/68 ; G01N33/569
Abstract:
The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of Desmoglein 2 (Dsg 2) mRNA or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of Desmoglein 2 mRNA or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of Desmoglein 2, and a monoclonal antibody binding specifically to human Desmoglein 2.
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