A guide and protection bushing assembly is mountable in a well production system (e.g., a subsea tree) having an intervention member (e.g., a blowout preventer). The assembly guides a string of components to a cable hanger sealing surface disposed in the production system without damaging the sealing surface. The assembly includes a body having a first end engaging an intervention member, a second end engaging the production system, an outer surface, and an inner through passage that expands radially at the first end to form a funnel shape. In some embodiments, the assembly may further include rollers, leaf springs, or a protective sleeve coupled to biasing members, a plurality of centering disks having a plurality of flexible flaps separated by spacers, and/or centering devices with fins separated by spacers. In some embodiments, the assembly may further include a hydraulically actuated plurality of rams, a piston with a plurality of protective elements, a plurality of nozzle jets, and/or a plurality of bladders.