The present disclosure provides a vehicle operation control method, device and system. The vehicle operation control method includes: receiving a vehicle operation instruction sent by a user terminal over a cellular network, which carries a vehicle identifier of an operated vehicle; searching stored correspondence relationships between vehicle identifiers and vehicle positional information for vehicle positional information of the operated vehicle according to the vehicle identifier, wherein the vehicle positional information is reported by the operated vehicle through a home road communication base station, and a signal coverage area of the home road communication base station covers the position where the operated vehicle is located; determining a device identifier of the home road communication base station of the operated vehicle according to the found vehicle positional information; and sending the vehicle operation instruction to the operated vehicle through the home road communication base station corresponding to the device identifier.