The present invention relates to a method and device for transmitting a signal by a transmitting end in a wireless communication system supporting multiple antennas including a plurality of vertical domain antennas and a plurality of horizontal domain antennas. Specifically, the present invention comprises the steps of: pre-coding a signal for multiple antennas, using a specific pre-coding matrix selected on the basis of a first codebook for the plurality of vertical domain antennas and a second codebook for the plurality of horizontal domain antennas; and transmitting the pre-coded signal to a receiving end, wherein the specific pre-coding matrix is defined by using a Kronecker product of a first pre-coding matrix selected from the first codebook according to at least one first selection vector and a second pre-coding matrix selected from the second codebook according to at least one second selection vector.