A system and method for establishing windows that govern the exchange of acknowledgements in a full-duplex communication. The window is established for two nodes which transmit asymmetric frame sizes in full-duplex mode. The window is related to the size of the asymmetric frames. Frames are exchanged in full-duplex between the two nodes, and the window size is defined as enabling the nodes to send data until the number of unacknowledged frames at the nodes is less than or equal to the window size, at which point acknowledgments are exchanged simultaneously. In sending the acknowledgment, both nodes can send acknowledgments simultaneously in full-duplex in the same frequency bin.