Method, device and computer-readable medium for enabling a virtual Subscriber Identity Module (SIM) card are provided in the disclosure, which belongs to a technical field of communication. The method includes: receiving an initiation instruction for initiating the virtual SIM card; detecting a current talk mode of a communication device based on the initiation instruction, the current talk mode includes a single-card mode; and installing a target talk mode corresponding to the current talk mode according to the current talk mode, the target talk mode includes a dual-card mode. The method and device for enabling a virtual SIM card may solve the problem that the virtual SIM card may not coexist with a physical SIM card in a single-card mode communication device, and may achieve an effect that the virtual SIM card and the physical SIM card may coexist with each other.