Systems and methods that employ an application-assisted approach to adaptive spatio-temporal error concealment in video decoders. The systems and methods employ a video receiver that can receive real-time video frames from a video transmitter over a wired and/or wireless network. The video receiver includes an end system configurable as an application for consuming the content of the real-time video frames. The end system application can determine whether each received real-time video frame is complete or incomplete, whether each received slice is complete or incomplete, and provide such information to the video decoder for use in avoiding errors while decoding the respective real-time video frames. The video decoder can determine whether any pixel blocks included in real-time video packets are properly decoded or missing, generate statistics regarding the coding mode of the respective pixel blocks, and use such further information while performing adaptive spatio-temporal error concealment on the respective pixel blocks.