Invention Grant
- Patent Title: Compounds that inhibit human DNA ligases and methods of treating cancer
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Application No.: US14729642Application Date: 2015-06-03
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Publication No.: US09757375B2Publication Date: 2017-09-12
- Inventor: Alan E. Tomkinson , Helen Xi Chen , Barbara Dziegielewska , Alexander D. Mackerell , Shijun Zhong , Gerald M. Wilson
- Applicant: University of Maryland, Baltimore
- Applicant Address: US MD Baltimore
- Assignee: University of Maryland, Baltimore
- Current Assignee: University of Maryland, Baltimore
- Current Assignee Address: US MD Baltimore
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: A61K31/165
- IPC: A61K31/165 ; A61K31/505 ; C40B30/02 ; G06F19/16 ; A61K31/166 ; A61K31/255 ; A61N5/10 ; G01N21/64 ; G06F19/00 ; A61K31/397 ; C07D307/68 ; A61K31/175 ; A61K31/341 ; A61K31/404 ; A61K31/41 ; A61K31/4184 ; A61K31/423 ; A61K31/4245 ; A61K31/428 ; A61K31/433 ; A61K31/436 ; A61K31/4439 ; A61K31/495 ; A61K31/553 ; A61K45/06 ; C07D209/30 ; C07D235/28 ; C07D257/04 ; C07D263/58 ; C07D267/18 ; C07D271/12 ; C07D277/74 ; C07D285/14 ; C07D401/12 ; C07D407/12
Abstract:
Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.
Public/Granted literature
- US20150313898A1 COMPOUNDS THAT INHIBIT HUMAN DNA LIGASES AND METHODS OF TREATING CANCER Public/Granted day:2015-11-05
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