A system includes an integrated manifold system including multiple isobaric pressure exchangers (IPXs) that each includes a low-pressure first fluid inlet, a high-pressure second fluid inlet, a high-pressure first fluid outlet, and a low-pressure second fluid outlet. The integrated manifold system includes a low-pressure first fluid manifold coupled to each of the low-pressure first fluid inlets and configured to provide low-pressure first fluid to each of the low-pressure first fluid inlets, a high-pressure second fluid manifold coupled to each of the high-pressure second fluid inlets and configured to provide high-pressure second fluid to each of the high-pressure second fluid inlets, a high-pressure first fluid manifold coupled to each of the high-pressure first fluid outlets and configured to discharge high-pressure first fluid, and a low-pressure second fluid manifold coupled to each of the low-pressure second fluid outlets and configured to discharge low-pressure second fluid.