Described herein is a method of removing refrigerant from a natural gas liquefaction system in which vaporized mixed refrigerant is withdrawn from the closed-loop refrigeration circuit and introduced into a distillation column so as to be separated into an overhead vapor enriched in methane and a bottoms liquid enriched in heavier components. Overhead vapor is withdrawn from the distillation column to form a methane enriched stream that is removed from the liquefaction system, and bottoms liquid is reintroduced from the distillation column into the closed-loop refrigeration circuit. Also described are methods of altering the rate of production in a natural gas liquefaction system in which refrigerant is removed as described above, and a natural gas liquefaction systems in which such methods can be carried out.