An image sensing device, a system and a method thereof and a charge sensing device are provided. The image sensing device includes a charge sensor, a pixel circuit, a selector and a pulse generator. The charge sensor includes a sensing electrode and generates an induced charge on the sensing electrode. The pixel circuit transforms the induced charge into a pixel voltage. Before the image sensing device outputs the pixel voltage, the pixel circuit receives a pulse voltage from the pulse generator such that at least one transistor in the pixel circuit raises a hot carrier injection effect, so as to amplify the induced charge on the sensing electrode.