Disclosed is a system for engaging and holding a prosthesis both axially and rotationally relative to an inserter assembly. The inserter assembly can engage an acetabular prosthesis in a selected position, such as axially, with a first portion and then or subsequently engage the acetabular prosthesis with a second portion in a rotationally fixed manner. The acetabular prosthesis can then be inserted into a prepared acetabulum according to a disclosed method with the inserter assembly. The inserter assembly can then be removed from the acetabular prosthesis to allow for reduction of a femur.