Invention Grant
- Patent Title: Non-aqueous taxane formulations and methods of using the same
-
Application No.: US15066087Application Date: 2016-03-10
-
Publication No.: US09763880B2Publication Date: 2017-09-19
- Inventor: Kiichiro Nabeta
- Applicant: Teikoku Pharma USA, Inc.
- Applicant Address: US CA San Jose
- Assignee: Teikoku Pharma USA, Inc.
- Current Assignee: Teikoku Pharma USA, Inc.
- Current Assignee Address: US CA San Jose
- Agency: Foley & Lardner LLP
- Main IPC: A61K31/335
- IPC: A61K31/335 ; A61K9/10 ; A61K31/337 ; A61K47/10 ; A61K47/12 ; A61K47/14 ; A61K47/26 ; A61K47/44

Abstract:
Non-aqueous, ethanol-free taxane formulations are provided. Formulations of embodiments of the invention include a taxane, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid component, wherein the organic acid component is soluble in the non-aqueous solvent and the amount by weight of non-ionic surfactant is equal to or greater than the amount by weight of non-aqueous solvent. Also provided are methods of using the formulations, as well as kits that include the formulations. Non-aqueous, ethanol-free docetaxel formulations are provided. Formulations of embodiments of the invention include docetaxel, an oil, a non-ionic surfactant, a non-aqueous solvent, and an organic acid which is soluble in the non-aqueous solvent and is substantially free of any conjugate base. Also provided are methods of using the formulations, as well as kits that include the formulations.
Public/Granted literature
- US20160206560A1 NON-AQUEOUS TAXANE FORMULATIONS AND METHODS OF USING THE SAME Public/Granted day:2016-07-21
Information query